Research Publications

1. Lu X, He Y, Johnston RL, Nanayakkara D, Sankarasubramanian S, Lopez JA, Friedlander M, Kalimutho M, Hooper JD, Raninga PV, Khanna KK. CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors. J Exp Clin Cancer Res. 2022;41(1):355. doi:10.1186/s13046-022-02570-4
2. Sinha D, Nag P, Nanayakkara D, Duijf PHG, Burgess A, Raninga P, Smits VAJ, Bain AL, Subramanian G, Wall M, Finnie JW, Kalimutho M, Khanna KK. Cep55 overexpression promotes genomic instability and tumorigenesis in mice. Commun Biol. 2020;3(1):593. doi:10.1038/s42003-020-01304-6
3. Duijf PHG, Nanayakkara D, Nones K, Srihari S, Kalimutho M, Khanna KK. Mechanisms of genomic instability in breast cancer. Trends Mol Med. 2019;25(7):595-611. doi:10.1016/j.molmed.2019.04.004
4. Yang RM, Nanayakkara D, Kalimutho M, Mitra P, Khanna KK, Dray E, Gonda TJ. MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells. Oncogene. 2019;38(28):5239-5249. doi:10.1038/s41388-019-0789-3
5. Kalimutho M, Sinha D, Mittal D, Srihari S, Nanayakkara D, Shafiqur S, Raninga P, Nag P, Parsons K, Khanna KK. Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. J Exp Clin Cancer Res. 2019;38:85. doi:10.1186/s13046-019-1075-5
6. Raninga PV, Lee AC, Sinha D, Shih Y, Mittal D, Makhale A, Bain AL, Nanayakkara D, Tonissen KF, Kalimutho M, Khanna KK. Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor, and anti-PD-L1 antibody for treatment of triple negative breast cancer. Int J Cancer. 2019;146(1):123-136. doi:10.1002/ijc.32410
7. Kalimutho M, Sinha D, Jeffery J, Nones K, Srihari S, Fernando WC, Duijf PHG, Vennin C, Raninga P, Nanayakkara D, Mittal D, Saunus JM, Lakhani SR, Lopez JA, Spring KJ, Timpson P, Gabrielli B, Waddell N, Khanna KK. CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Mol Med. 2018;10(12):e8566. doi:10.15252/emmm.201708566
8. Anderson AM, Kalimutho M, Harten S, Nanayakkara DM, Khanna KK, Ragan MA. The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells. Sci Rep. 2017;7:39873. doi:10.1038/srep39873
9. Kalimutho M, Bain AL, Mukherjee B, Nag P, Nanayakkara DM, Harten SK, Harris JL, Subramanian GN, Sinha D, Shirasawa S, Srihari S, Burma S, Khanna KK. Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. Mol Oncol. 2017;11(5):470-490. doi:10.1002/1878-0261.12034
10. Bridges CR, Tan M, Premarathne S, Nanayakkara DM, Bellette B, Zencak D, Domingo D, Gecz J, Murtaza M, Jolly L, Wood SA. USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors. Sci Rep. 2017;7:391. doi:10.1038/s41598-017-00149-0
11. Nanayakkara DM, Nguyen M, Wood SA. Deubiquitylating enzyme, USP9X, promotes proliferation of head and neck cancer cell lines. Cell Prolif. 2016;49(4):494-502. doi:10.1111/cpr.12273
12. Nanayakkara DM, Rajapakse RPVJ, Wickramasinghe S, Kularatne SAM. Serological evidence for exposure of dogs to Rickettsia conorii, Rickettsia typhi, and Orientia tsutsugamushi in Sri Lanka. Vector Borne Zoonotic Dis. 2013;13(8):545-549. doi:10.1089/vbz.2012.1049
13. Kularatne SAM, Rajapakse RPVJ, Wickramasinghe S, Nanayakkara DM, Budagoda SS, Weerakoon KGAD, Edirisinghe JS, Premaratne R. Rickettsioses in the central hills of Sri Lanka: serological evidence of increasing burden of spotted fever group. Int J Infect Dis. 2013;17(11):e988-e992. doi:10.1016/j.ijid.2013.05.014
14. Kularatne SAM, Weerakoon KGAD, Rajapakse RPVJ, Madagedara SC, Nanayakkara D, Premaratna R. A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. Int J Infect Dis. 2012;16(7):e548-e553. doi:10.1016/j.ijid.2012.02.016